Job Description

Overview

Scientist / Study Director In Vivo Pharmacology, DMPK & Toxicology

Location: San Diego, California
Department: Preclinical Research
Reports to: Director of Preclinical Sciences

About BioLegacy Research
BioLegacy Research is a fast-growing preclinical research organization advancing drug discovery and development through high-quality in vivo pharmacology, DMPK, and toxicology studies. We partner with biotechnology and pharmaceutical companies to deliver reliable, GLP-compliant data that support IND-enabling and discovery programs. We are seeking a Scientist / Study Director with broad experience in in vivo pharmacology, drug metabolism and pharmacokinetics (DMPK), and toxicology, capable of leading complex preclinical studies across multiple animal species. The ideal candidate will have a strong record in study design, model development, data interpretation, and cross-functional coordination.

Key Responsibilities

• In Vivo & Preclinical Leadership
• Design, conduct, and oversee in vivo pharmacology, PK/TK, and toxicology studies in rodents and large animals (including dogs, monkeys, rabbits, and pigs).
• Serve as Study Director or Principal Investigator for GLP and nonGLP studies, ensuring regulatory compliance, data integrity, and scientific rigor.
• Develop and refine disease models in therapeutic areas such as cardiovascular, metabolic, oncology, renal, inflammation, fibrosis, and ophthalmology.
• Execute and guide complex surgical and dosing procedures (IV, IP, SC, PO, inhalation, infusion, minipump implantation, and gene delivery).
• Collaborate with bioanalytical, toxicology, and formulation teams to integrate PK/PD and ADME data into study reports.
• Write study protocols, amendments, IACUC submissions, and final reports.

DMPK & Pharmacokinetic Expertise

• Design studies to characterize absorption, distribution, metabolism, and excretion (ADME) profiles of test articles.
• Analyze and interpret PK/PD and exposureresponse data across species to support dose selection and safety evaluation.
• Partner with bioanalytical scientists on sampling strategy, assay validation, and data review.
• Provide DMPK input for discovery, translational, and IND-enabling programs.

Toxicology & Safety Assessment

• Support toxicology and safety pharmacology study design and data interpretation.
• Collaborate with toxicologists, veterinarians, and pathologists to evaluate safety, tolerability, and mechanism-related findings.
• Participate in the generation of reports for regulatory submissions and sponsor presentations.

Cross-Functional Collaboration & Client Support

• Act as the scientific liaison between sponsors and internal functional teams.
• Present data and study progress in internal meetings and client updates.
• Contribute to proposal development and study quotations, providing scientific input on scope and design.
• Mentor junior scientists and ensure high standards of technical training and animal welfare.

Qualifications

• Ph.D. or M.S. in Pharmacology, Toxicology, Pharmaceutical Sciences, or related life science.
• Minimum 5 years of experience in in vivo pharmacology, DMPK, or toxicology within a CRO, biotech, or pharmaceutical environment.
• Proven record as a Study Director or lead scientist managing multispecies preclinical studies.
• Deep understanding of cardiovascular, renal, metabolic, inflammatory, and oncology models.
• Skilled in animal handling, surgical techniques, and physiological monitoring (e.g., telemetry, echocardiography, pressure-volume loop systems).
• Familiar with GLP, IACUC, and FDA regulatory expectations for preclinical studies.
• Excellent skills in scientific writing, data interpretation, and crossfunctional communication.
• Highly organized, detail-oriented, and capable of managing multiple concurrent studies.

Why Join BioLegacy Research

• Lead innovative in vivo and DMPK studies supporting translational and IND-enabling programs.
• Work across diverse therapeutic areas and animal models.
• Collaborate with experienced scientists in a growing, research-driven environment.
• Competitive compensation, performance incentives, and professional growth opportunities.
• Commitment to scientific integrity, innovation, and animal welfare.

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